Catalog Number - 70000-P30-50

The 70000‑P30‑50 Diamond Hydride Preparative HPLC Column is designed for high‑load, high‑throughput purification processes where analytes are collected for downstream research, development, or commercial use. This short‑bed, large‑diameter preparative column maximizes sample capacity and productivity when rapid separations are required and resolution demands are moderate.

Preparative Use Case: Why 30 mm ID × 50 mm

The 30 mm internal diameter places this column firmly in the true preparative scale, intended for laboratories conducting large‑volume injections and collecting significant quantities of purified analytes for further processing or sale.

The 50 mm column length offers specific advantages for process‑oriented purification:

• Extremely high sample loading capacity

• Short run times for rapid batch turnaround

• Lower backpressure at very high flow rates

• Efficient solvent use in repetitive purification cycles

This configuration is typically selected when throughput and capacity outweigh maximum resolution, andwhen analytes of interest are already well resolved under optimized HILIC conditions.

Diamond Hydride™ TYPE‑C Stationary Phase Advantages

Manufactured using Cogent TYPE‑C™ silica hydride technology, the Diamond Hydride stationary phase delivers robust, reproducible performance for preparative‑scale HILIC separations:

• Stable and consistent retention of polar compounds

• Faster equilibration than conventional bonded‑silica HILIC phases

• Excellent chemical stability under high‑organic mobile phases

• Long operating life in continuous or repeated purification workflows

This stationary phase is particularly well suited for purification of:

• Peptides and peptide‑like compounds

• Metabolites and highly polar small molecules

• Amine‑containing and basic analytes

• Compounds isolated using HILIC‑based retention mechanisms

Purpose‑Built for Process & Production‑Scale Purification

The 70000‑P30‑50 supports predictable scale‑up from smaller preparative formats while maintaining chromatographic behavior. It is frequently used in process development, pilot‑scale purification, and production‑oriented workflows where purified analytes are required for continued research, formulation, or commercial supply.

System Requirements

Typical operating flow rates: ~40–80 mL/min

This column requires a dedicated preparative or process‑scale HPLC system capable of:

• Sustained very high flow‑rate operation

• Large injection volumes

• High‑capacity pumping and solvent delivery

• Suitable detectors and fraction collection hardware

Analytical and semi‑preparative HPLC systems are not suitable for 30 mm ID preparative columns.

Flow rates must be optimized based on mobile‑phase composition, viscosity, pressure limits, and process objectives.

Made‑to‑Order Columns & Pricing Information

These columns represent a significant investment and are frequently application‑specific. To ensure customers receive the correct column for their workflow:

• Pricing and technical support are provided through our Customer Service Department via formal quotation

• Columns are produced on order, based on customer requirements

• Orders cannot be canceled or returned once placed

• Learn more about Custom Orders and our Custom Order policies.